goodduck

sentinel cell recognition pathogen -> initiate and amplify innate immunity

1.sentinel cell 

   macrophage: "patrol" in alveoli,
   denritic cell: throught airway, innate -> type 1 interferon ; adaptive -> to L.N as APC
   lung epithelium

2.recognition patogen

   pattern-recognition receptor (intra/extracelluar/ transmembrane)

3.initiate and amplify innate immunity

iNKT-------------------->
macrophage--------->    epithelium activation    -->  cytokine/ chemokine/ adhesion molecule/CSF
macrophage--> IL-->
microbe  -------------->

4. inflammation and acute lung injury

# pneumoccci -> DNase -> cleave NETs
   influenza -> protein bind cytosolic receptor
   P. aeruginosa -> "listen  immune conversation" -> when presence interferon-r -> biofilm formation
                                                                                                                -> when presence TNF -> growth rate increase